CorSalud 2012 Oct-Dec;4(4)

This article is only available in Spanish

Javier E. Herrera-Villalobos, MD^1,2; Paloma A. Sil Jaimes, MD^1,2; Fausto M. Pinal González, MD²; Adriana Garduño Alanís, MSc²; Acela M. Santamaría Benhumea, MDN² and José P. Rueda Villalpando, MD²
______________

1. Critical Care Unit in Obstetrics at the Infant and Maternity Hospital of the Social Security Institute of Mexico State and Municipalities.

2. Research Unit at Mónica Pretelini Sáenz Maternal and Perinatal Hospital of the Health Institute of Mexico State.

Correspondence: JE Herrera−Villalobos. Paseo Tollocan sin número, Col. Universidad; Toluca. México 50130. Telephone: (722) 2-76-55-40. Email address: je_herrera44@hotmail.com

Abstract

Introduction and Objectives: Pregnancy−induced hypertension or preeclampsia presents pathophysiological features similar to atherosclerosis and cardiovascular disease. Identify atherogenic risk factors and their relationship in preeclampsia was the purpose of this study. Method: We conducted a cross−sectional descriptive research, with 50 patients in the third trimester of pregnancy. Weight and height, to calculate body mass index, were established through the interview. Blood pressure >140/90 mmHg accompanied by edema and proteinuria in pregnancy, was classified as hypertension. Blood samples were taken to determine the values of serum cholesterol, triglyceride and HDL. The variables are expressed as percentages. Results: The number of risk factors and their associations were analyzed in each patient. The most important result was that 76% were overweight or obese. The preeclampsia syndrome, was found in 30% of patients with a relative risk of 3 times the normal lipid profile, and 30% had a high atherogenic index. Conclusions: Dyslipidemia is an important atherogenic risk factor, together constitute a risk factor for preeclampsia. The increment of atherogenic index increases susceptibility to atherogenesis in preeclampsia. Dyslipidemia appears to be the starting point of these subsequent events. The study of the role of dyslipidemia could contribute to the understanding of the mechanisms of endothelial dysfunction in preeclampsia.
Key words: Atherogenic index, Pregnancy, Risk factors, Pre−Eclampsia